International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma.
Identifieur interne : 001C50 ( Main/Exploration ); précédent : 001C49; suivant : 001C51International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma.
Auteurs : Shaji Kumar [États-Unis] ; Bruno Paiva [Espagne] ; Kenneth C. Anderson [États-Unis] ; Brian Durie [États-Unis] ; Ola Landgren [États-Unis] ; Philippe Moreau [France] ; Nikhil Munshi [États-Unis] ; Sagar Lonial [États-Unis] ; Joan Bladé [Espagne] ; Maria-Victoria Mateos [Espagne] ; Meletios Dimopoulos [Grèce] ; Efstathios Kastritis [Grèce] ; Mario Boccadoro [États-Unis] ; Robert Orlowski [États-Unis] ; Hartmut Goldschmidt [Allemagne] ; Andrew Spencer [Australie] ; Jian Hou [République populaire de Chine] ; Wee Joo Chng [Singapour] ; Saad Z. Usmani [États-Unis] ; Elena Zamagni [Italie] ; Kazuyuki Shimizu [Japon] ; Sundar Jagannath [États-Unis] ; Hans E. Johnsen [Danemark] ; Evangelos Terpos [Grèce] ; Anthony Reiman [Canada] ; Robert A. Kyle [États-Unis] ; Pieter Sonneveld [Pays-Bas] ; Paul G. Richardson [États-Unis] ; Philip Mccarthy [États-Unis] ; Heinz Ludwig [Autriche] ; Wenming Chen [République populaire de Chine] ; Michele Cavo [Italie] ; Jean-Luc Harousseau [France] ; Suzanne Lentzsch [États-Unis] ; Jens Hillengass [Allemagne] ; Antonio Palumbo [Italie] ; Alberto Orfao [Espagne] ; S Vincent Rajkumar [États-Unis] ; Jesus San Miguel [Espagne] ; Herve Avet-Loiseau [France]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Maladie résiduelle.
- effets indésirables : Protocoles de polychimiothérapie antinéoplasique.
- normes : Guides de bonnes pratiques cliniques comme sujet.
- traitement médicamenteux : Myélome multiple.
- Consensus, Humains, Maladie résiduelle.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Antineoplastic Combined Chemotherapy Protocols.
- chemically induced : Neoplasm, Residual.
- diagnosis : Neoplasm, Residual.
- drug therapy : Multiple Myeloma.
- standards : Practice Guidelines as Topic.
- Consensus, Humans.
Abstract
Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment (which is relatively insensitive). Given the high rates of complete response seen in patients with multiple myeloma with new treatment approaches, new response categories need to be defined that can identify responses that are deeper than those conventionally defined as complete response. Recent attempts have focused on the identification of residual tumour cells in the bone marrow using flow cytometry or gene sequencing. Furthermore, sensitive imaging techniques can be used to detect the presence of residual disease outside of the bone marrow. Combining these new methods, the International Myeloma Working Group has defined new response categories of minimal residual disease negativity, with or without imaging-based absence of extramedullary disease, to allow uniform reporting within and outside clinical trials. In this Review, we clarify several aspects of disease response assessment, along with endpoints for clinical trials, and highlight future directions for disease response assessments.
DOI: 10.1016/S1470-2045(16)30206-6
PubMed: 27511158
Affiliations:
- Allemagne, Australie, Autriche, Canada, Danemark, Espagne, France, Grèce, Italie, Japon, Pays-Bas, République populaire de Chine, Singapour, États-Unis
- Attique (région), Bade-Wurtemberg, Californie, Caroline du Nord, Catalogne, District de Karlsruhe, Géorgie (États-Unis), Hollande-Méridionale, Massachusetts, Midi-Pyrénées, Minnesota, Occitanie (région administrative), Pays de la Loire, Piémont, Texas, Vienne (Autriche), État de New York
- Athènes, Barcelone, Heidelberg, Nantes, New York, Pékin, Rotterdam, Toulouse, Turin, Vienne (Autriche)
- Université Columbia
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Cancer Institute, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lonial, Sagar" sort="Lonial, Sagar" uniqKey="Lonial S" first="Sagar" last="Lonial">Sagar Lonial</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Blade, Joan" sort="Blade, Joan" uniqKey="Blade J" first="Joan" last="Bladé">Joan Bladé</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Mateos, Maria Victoria" sort="Mateos, Maria Victoria" uniqKey="Mateos M" first="Maria-Victoria" last="Mateos">Maria-Victoria Mateos</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital of Salamanca/IBSAL, Salamanca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital of Salamanca/IBSAL, Salamanca</wicri:regionArea><wicri:noRegion>Salamanca</wicri:noRegion></affiliation></author><author><name sortKey="Dimopoulos, Meletios" sort="Dimopoulos, Meletios" uniqKey="Dimopoulos M" first="Meletios" last="Dimopoulos">Meletios Dimopoulos</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Kastritis, Efstathios" sort="Kastritis, Efstathios" uniqKey="Kastritis E" first="Efstathios" last="Kastritis">Efstathios Kastritis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Boccadoro, Mario" sort="Boccadoro, Mario" uniqKey="Boccadoro M" first="Mario" last="Boccadoro">Mario Boccadoro</name><affiliation wicri:level="2"><nlm:affiliation>Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino, Torino, Italy; Mount Sinai Cancer Institute, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino, Torino, Italy; Mount Sinai Cancer Institute, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Orlowski, Robert" sort="Orlowski, Robert" uniqKey="Orlowski R" first="Robert" last="Orlowski">Robert Orlowski</name><affiliation wicri:level="2"><nlm:affiliation>MD Anderson Comprehensive Cancer Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>MD Anderson Comprehensive Cancer Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Goldschmidt, Hartmut" sort="Goldschmidt, Hartmut" uniqKey="Goldschmidt H" first="Hartmut" last="Goldschmidt">Hartmut Goldschmidt</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name><affiliation wicri:level="1"><nlm:affiliation>The Alfred Hospital, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Alfred Hospital, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Hou, Jian" sort="Hou, Jian" uniqKey="Hou J" first="Jian" last="Hou">Jian Hou</name><affiliation wicri:level="1"><nlm:affiliation>Chang Zheng Hospital, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chang Zheng Hospital, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Chng, Wee Joo" sort="Chng, Wee Joo" uniqKey="Chng W" first="Wee Joo" last="Chng">Wee Joo Chng</name><affiliation wicri:level="1"><nlm:affiliation>National University Health System, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University Health System</wicri:regionArea></affiliation></author><author><name sortKey="Usmani, Saad Z" sort="Usmani, Saad Z" uniqKey="Usmani S" first="Saad Z" last="Usmani">Saad Z. Usmani</name><affiliation wicri:level="2"><nlm:affiliation>Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Zamagni, Elena" sort="Zamagni, Elena" uniqKey="Zamagni E" first="Elena" last="Zamagni">Elena Zamagni</name><affiliation wicri:level="1"><nlm:affiliation>Seragnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Seragnoli Institute of Hematology, Bologna University School of Medicine, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Shimizu, Kazuyuki" sort="Shimizu, Kazuyuki" uniqKey="Shimizu K" first="Kazuyuki" last="Shimizu">Kazuyuki Shimizu</name><affiliation wicri:level="1"><nlm:affiliation>Tokai Central Hospital, Kakamigahara, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tokai Central Hospital, Kakamigahara</wicri:regionArea><wicri:noRegion>Kakamigahara</wicri:noRegion></affiliation></author><author><name sortKey="Jagannath, Sundar" sort="Jagannath, Sundar" uniqKey="Jagannath S" first="Sundar" last="Jagannath">Sundar Jagannath</name><affiliation wicri:level="2"><nlm:affiliation>Mount Sinai Cancer Institute, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mount Sinai Cancer Institute, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Johnsen, Hans E" sort="Johnsen, Hans E" uniqKey="Johnsen H" first="Hans E" last="Johnsen">Hans E. Johnsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg</wicri:regionArea><wicri:noRegion>Aalborg</wicri:noRegion></affiliation></author><author><name sortKey="Terpos, Evangelos" sort="Terpos, Evangelos" uniqKey="Terpos E" first="Evangelos" last="Terpos">Evangelos Terpos</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Reiman, Anthony" sort="Reiman, Anthony" uniqKey="Reiman A" first="Anthony" last="Reiman">Anthony Reiman</name><affiliation wicri:level="1"><nlm:affiliation>Dalhousie University Medical School, Dalhousie, Nova Scotia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Dalhousie University Medical School, Dalhousie, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author><author><name sortKey="Kyle, Robert A" sort="Kyle, Robert A" uniqKey="Kyle R" first="Robert A" last="Kyle">Robert A. Kyle</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Sonneveld, Pieter" sort="Sonneveld, Pieter" uniqKey="Sonneveld P" first="Pieter" last="Sonneveld">Pieter Sonneveld</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Richardson, Paul G" sort="Richardson, Paul G" uniqKey="Richardson P" first="Paul G" last="Richardson">Paul G. Richardson</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name><affiliation wicri:level="2"><nlm:affiliation>Roswell Park Cancer Institute, Buffalo, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Roswell Park Cancer Institute, Buffalo, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name><affiliation wicri:level="3"><nlm:affiliation>Wilhelminenspital Der Stat Wien, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Wilhelminenspital Der Stat Wien, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Chen, Wenming" sort="Chen, Wenming" uniqKey="Chen W" first="Wenming" last="Chen">Wenming Chen</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Chaoyang Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Chaoyang Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cavo, Michele" sort="Cavo, Michele" uniqKey="Cavo M" first="Michele" last="Cavo">Michele Cavo</name><affiliation wicri:level="1"><nlm:affiliation>Seragnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Seragnoli Institute of Hematology, Bologna University School of Medicine, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Harousseau, Jean Luc" sort="Harousseau, Jean Luc" uniqKey="Harousseau J" first="Jean-Luc" last="Harousseau">Jean-Luc Harousseau</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Lentzsch, Suzanne" sort="Lentzsch, Suzanne" uniqKey="Lentzsch S" first="Suzanne" last="Lentzsch">Suzanne Lentzsch</name><affiliation wicri:level="4"><nlm:affiliation>Columbia University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Hillengass, Jens" sort="Hillengass, Jens" uniqKey="Hillengass J" first="Jens" last="Hillengass">Jens Hillengass</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name><affiliation wicri:level="3"><nlm:affiliation>Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino, Torino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Orfao, Alberto" sort="Orfao, Alberto" uniqKey="Orfao A" first="Alberto" last="Orfao">Alberto Orfao</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital of Salamanca/IBSAL, Salamanca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital of Salamanca/IBSAL, Salamanca</wicri:regionArea><wicri:noRegion>Salamanca</wicri:noRegion></affiliation></author><author><name sortKey="Rajkumar, S Vincent" sort="Rajkumar, S Vincent" uniqKey="Rajkumar S" first="S Vincent" last="Rajkumar">S Vincent Rajkumar</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Miguel, Jesus San" sort="Miguel, Jesus San" uniqKey="Miguel J" first="Jesus San" last="Miguel">Jesus San Miguel</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), Pamplona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Avet Loiseau, Herve" sort="Avet Loiseau, Herve" uniqKey="Avet Loiseau H" first="Herve" last="Avet-Loiseau">Herve Avet-Loiseau</name><affiliation wicri:level="3"><nlm:affiliation>University of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27511158</idno><idno type="pmid">27511158</idno><idno type="doi">10.1016/S1470-2045(16)30206-6</idno><idno type="wicri:Area/PubMed/Corpus">001A24</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A24</idno><idno type="wicri:Area/PubMed/Curation">001A00</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A00</idno><idno type="wicri:Area/PubMed/Checkpoint">001A00</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001A00</idno><idno type="wicri:Area/Ncbi/Merge">003972</idno><idno type="wicri:Area/Ncbi/Curation">003972</idno><idno type="wicri:Area/Ncbi/Checkpoint">003972</idno><idno type="wicri:Area/Main/Merge">001C47</idno><idno type="wicri:Area/Main/Curation">001C50</idno><idno type="wicri:Area/Main/Exploration">001C50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma.</title><author><name sortKey="Kumar, Shaji" sort="Kumar, Shaji" uniqKey="Kumar S" first="Shaji" last="Kumar">Shaji Kumar</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology, Mayo Clinic, Rochester, MN, USA. Electronic address: kumar.shaji@mayo.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Paiva, Bruno" sort="Paiva, Bruno" uniqKey="Paiva B" first="Bruno" last="Paiva">Bruno Paiva</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), Pamplona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, Kenneth C" sort="Anderson, Kenneth C" uniqKey="Anderson K" first="Kenneth C" last="Anderson">Kenneth C. Anderson</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Durie, Brian" sort="Durie, Brian" uniqKey="Durie B" first="Brian" last="Durie">Brian Durie</name><affiliation wicri:level="2"><nlm:affiliation>Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars-Sinai Comprehensive Cancer Center, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Landgren, Ola" sort="Landgren, Ola" uniqKey="Landgren O" first="Ola" last="Landgren">Ola Landgren</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Moreau, Philippe" sort="Moreau, Philippe" uniqKey="Moreau P" first="Philippe" last="Moreau">Philippe Moreau</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Munshi, Nikhil" sort="Munshi, Nikhil" uniqKey="Munshi N" first="Nikhil" last="Munshi">Nikhil Munshi</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lonial, Sagar" sort="Lonial, Sagar" uniqKey="Lonial S" first="Sagar" last="Lonial">Sagar Lonial</name><affiliation wicri:level="2"><nlm:affiliation>Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Blade, Joan" sort="Blade, Joan" uniqKey="Blade J" first="Joan" last="Bladé">Joan Bladé</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clinic, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinic, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Mateos, Maria Victoria" sort="Mateos, Maria Victoria" uniqKey="Mateos M" first="Maria-Victoria" last="Mateos">Maria-Victoria Mateos</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital of Salamanca/IBSAL, Salamanca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital of Salamanca/IBSAL, Salamanca</wicri:regionArea><wicri:noRegion>Salamanca</wicri:noRegion></affiliation></author><author><name sortKey="Dimopoulos, Meletios" sort="Dimopoulos, Meletios" uniqKey="Dimopoulos M" first="Meletios" last="Dimopoulos">Meletios Dimopoulos</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Kastritis, Efstathios" sort="Kastritis, Efstathios" uniqKey="Kastritis E" first="Efstathios" last="Kastritis">Efstathios Kastritis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Boccadoro, Mario" sort="Boccadoro, Mario" uniqKey="Boccadoro M" first="Mario" last="Boccadoro">Mario Boccadoro</name><affiliation wicri:level="2"><nlm:affiliation>Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino, Torino, Italy; Mount Sinai Cancer Institute, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino, Torino, Italy; Mount Sinai Cancer Institute, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Orlowski, Robert" sort="Orlowski, Robert" uniqKey="Orlowski R" first="Robert" last="Orlowski">Robert Orlowski</name><affiliation wicri:level="2"><nlm:affiliation>MD Anderson Comprehensive Cancer Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>MD Anderson Comprehensive Cancer Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Goldschmidt, Hartmut" sort="Goldschmidt, Hartmut" uniqKey="Goldschmidt H" first="Hartmut" last="Goldschmidt">Hartmut Goldschmidt</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name><affiliation wicri:level="1"><nlm:affiliation>The Alfred Hospital, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Alfred Hospital, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Hou, Jian" sort="Hou, Jian" uniqKey="Hou J" first="Jian" last="Hou">Jian Hou</name><affiliation wicri:level="1"><nlm:affiliation>Chang Zheng Hospital, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chang Zheng Hospital, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Chng, Wee Joo" sort="Chng, Wee Joo" uniqKey="Chng W" first="Wee Joo" last="Chng">Wee Joo Chng</name><affiliation wicri:level="1"><nlm:affiliation>National University Health System, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University Health System</wicri:regionArea></affiliation></author><author><name sortKey="Usmani, Saad Z" sort="Usmani, Saad Z" uniqKey="Usmani S" first="Saad Z" last="Usmani">Saad Z. Usmani</name><affiliation wicri:level="2"><nlm:affiliation>Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Zamagni, Elena" sort="Zamagni, Elena" uniqKey="Zamagni E" first="Elena" last="Zamagni">Elena Zamagni</name><affiliation wicri:level="1"><nlm:affiliation>Seragnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Seragnoli Institute of Hematology, Bologna University School of Medicine, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Shimizu, Kazuyuki" sort="Shimizu, Kazuyuki" uniqKey="Shimizu K" first="Kazuyuki" last="Shimizu">Kazuyuki Shimizu</name><affiliation wicri:level="1"><nlm:affiliation>Tokai Central Hospital, Kakamigahara, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tokai Central Hospital, Kakamigahara</wicri:regionArea><wicri:noRegion>Kakamigahara</wicri:noRegion></affiliation></author><author><name sortKey="Jagannath, Sundar" sort="Jagannath, Sundar" uniqKey="Jagannath S" first="Sundar" last="Jagannath">Sundar Jagannath</name><affiliation wicri:level="2"><nlm:affiliation>Mount Sinai Cancer Institute, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mount Sinai Cancer Institute, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Johnsen, Hans E" sort="Johnsen, Hans E" uniqKey="Johnsen H" first="Hans E" last="Johnsen">Hans E. Johnsen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg</wicri:regionArea><wicri:noRegion>Aalborg</wicri:noRegion></affiliation></author><author><name sortKey="Terpos, Evangelos" sort="Terpos, Evangelos" uniqKey="Terpos E" first="Evangelos" last="Terpos">Evangelos Terpos</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Reiman, Anthony" sort="Reiman, Anthony" uniqKey="Reiman A" first="Anthony" last="Reiman">Anthony Reiman</name><affiliation wicri:level="1"><nlm:affiliation>Dalhousie University Medical School, Dalhousie, Nova Scotia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Dalhousie University Medical School, Dalhousie, Nova Scotia</wicri:regionArea><wicri:noRegion>Nova Scotia</wicri:noRegion></affiliation></author><author><name sortKey="Kyle, Robert A" sort="Kyle, Robert A" uniqKey="Kyle R" first="Robert A" last="Kyle">Robert A. Kyle</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Sonneveld, Pieter" sort="Sonneveld, Pieter" uniqKey="Sonneveld P" first="Pieter" last="Sonneveld">Pieter Sonneveld</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Richardson, Paul G" sort="Richardson, Paul G" uniqKey="Richardson P" first="Paul G" last="Richardson">Paul G. Richardson</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name><affiliation wicri:level="2"><nlm:affiliation>Roswell Park Cancer Institute, Buffalo, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Roswell Park Cancer Institute, Buffalo, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name><affiliation wicri:level="3"><nlm:affiliation>Wilhelminenspital Der Stat Wien, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Wilhelminenspital Der Stat Wien, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Chen, Wenming" sort="Chen, Wenming" uniqKey="Chen W" first="Wenming" last="Chen">Wenming Chen</name><affiliation wicri:level="3"><nlm:affiliation>Beijing Chaoyang Hospital, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Chaoyang Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cavo, Michele" sort="Cavo, Michele" uniqKey="Cavo M" first="Michele" last="Cavo">Michele Cavo</name><affiliation wicri:level="1"><nlm:affiliation>Seragnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Seragnoli Institute of Hematology, Bologna University School of Medicine, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Harousseau, Jean Luc" sort="Harousseau, Jean Luc" uniqKey="Harousseau J" first="Jean-Luc" last="Harousseau">Jean-Luc Harousseau</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Lentzsch, Suzanne" sort="Lentzsch, Suzanne" uniqKey="Lentzsch S" first="Suzanne" last="Lentzsch">Suzanne Lentzsch</name><affiliation wicri:level="4"><nlm:affiliation>Columbia University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Hillengass, Jens" sort="Hillengass, Jens" uniqKey="Hillengass J" first="Jens" last="Hillengass">Jens Hillengass</name><affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name><affiliation wicri:level="3"><nlm:affiliation>Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino, Torino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Myeloma Unit, Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino, Torino</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Orfao, Alberto" sort="Orfao, Alberto" uniqKey="Orfao A" first="Alberto" last="Orfao">Alberto Orfao</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital of Salamanca/IBSAL, Salamanca, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>University Hospital of Salamanca/IBSAL, Salamanca</wicri:regionArea><wicri:noRegion>Salamanca</wicri:noRegion></affiliation></author><author><name sortKey="Rajkumar, S Vincent" sort="Rajkumar, S Vincent" uniqKey="Rajkumar S" first="S Vincent" last="Rajkumar">S Vincent Rajkumar</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Miguel, Jesus San" sort="Miguel, Jesus San" uniqKey="Miguel J" first="Jesus San" last="Miguel">Jesus San Miguel</name><affiliation wicri:level="1"><nlm:affiliation>Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), Pamplona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Avet Loiseau, Herve" sort="Avet Loiseau, Herve" uniqKey="Avet Loiseau H" first="Herve" last="Avet-Loiseau">Herve Avet-Loiseau</name><affiliation wicri:level="3"><nlm:affiliation>University of Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols (adverse effects)</term><term>Consensus</term><term>Humans</term><term>Multiple Myeloma (drug therapy)</term><term>Neoplasm, Residual (chemically induced)</term><term>Neoplasm, Residual (diagnosis)</term><term>Practice Guidelines as Topic (standards)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Consensus</term><term>Guides de bonnes pratiques cliniques comme sujet (normes)</term><term>Humains</term><term>Maladie résiduelle ()</term><term>Maladie résiduelle (diagnostic)</term><term>Myélome multiple (traitement médicamenteux)</term><term>Protocoles de polychimiothérapie antinéoplasique (effets indésirables)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Neoplasm, Residual</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Neoplasm, Residual</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladie résiduelle</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Multiple Myeloma</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Guides de bonnes pratiques cliniques comme sujet</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Practice Guidelines as Topic</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Myélome multiple</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Consensus</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Consensus</term><term>Humains</term><term>Maladie résiduelle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment (which is relatively insensitive). Given the high rates of complete response seen in patients with multiple myeloma with new treatment approaches, new response categories need to be defined that can identify responses that are deeper than those conventionally defined as complete response. Recent attempts have focused on the identification of residual tumour cells in the bone marrow using flow cytometry or gene sequencing. Furthermore, sensitive imaging techniques can be used to detect the presence of residual disease outside of the bone marrow. Combining these new methods, the International Myeloma Working Group has defined new response categories of minimal residual disease negativity, with or without imaging-based absence of extramedullary disease, to allow uniform reporting within and outside clinical trials. In this Review, we clarify several aspects of disease response assessment, along with endpoints for clinical trials, and highlight future directions for disease response assessments.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Japon</li><li>Pays-Bas</li><li>République populaire de Chine</li><li>Singapour</li><li>États-Unis</li></country><region><li>Attique (région)</li><li>Bade-Wurtemberg</li><li>Californie</li><li>Caroline du Nord</li><li>Catalogne</li><li>District de Karlsruhe</li><li>Géorgie (États-Unis)</li><li>Hollande-Méridionale</li><li>Massachusetts</li><li>Midi-Pyrénées</li><li>Minnesota</li><li>Occitanie (région administrative)</li><li>Pays de la Loire</li><li>Piémont</li><li>Texas</li><li>Vienne (Autriche)</li><li>État de New York</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Heidelberg</li><li>Nantes</li><li>New York</li><li>Pékin</li><li>Rotterdam</li><li>Toulouse</li><li>Turin</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Kumar, Shaji" sort="Kumar, Shaji" uniqKey="Kumar S" first="Shaji" last="Kumar">Shaji Kumar</name></region><name sortKey="Anderson, Kenneth C" sort="Anderson, Kenneth C" uniqKey="Anderson K" first="Kenneth C" last="Anderson">Kenneth C. Anderson</name><name sortKey="Boccadoro, Mario" sort="Boccadoro, Mario" uniqKey="Boccadoro M" first="Mario" last="Boccadoro">Mario Boccadoro</name><name sortKey="Durie, Brian" sort="Durie, Brian" uniqKey="Durie B" first="Brian" last="Durie">Brian Durie</name><name sortKey="Jagannath, Sundar" sort="Jagannath, Sundar" uniqKey="Jagannath S" first="Sundar" last="Jagannath">Sundar Jagannath</name><name sortKey="Kyle, Robert A" sort="Kyle, Robert A" uniqKey="Kyle R" first="Robert A" last="Kyle">Robert A. Kyle</name><name sortKey="Landgren, Ola" sort="Landgren, Ola" uniqKey="Landgren O" first="Ola" last="Landgren">Ola Landgren</name><name sortKey="Lentzsch, Suzanne" sort="Lentzsch, Suzanne" uniqKey="Lentzsch S" first="Suzanne" last="Lentzsch">Suzanne Lentzsch</name><name sortKey="Lonial, Sagar" sort="Lonial, Sagar" uniqKey="Lonial S" first="Sagar" last="Lonial">Sagar Lonial</name><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name><name sortKey="Munshi, Nikhil" sort="Munshi, Nikhil" uniqKey="Munshi N" first="Nikhil" last="Munshi">Nikhil Munshi</name><name sortKey="Orlowski, Robert" sort="Orlowski, Robert" uniqKey="Orlowski R" first="Robert" last="Orlowski">Robert Orlowski</name><name sortKey="Rajkumar, S Vincent" sort="Rajkumar, S Vincent" uniqKey="Rajkumar S" first="S Vincent" last="Rajkumar">S Vincent Rajkumar</name><name sortKey="Richardson, Paul G" sort="Richardson, Paul G" uniqKey="Richardson P" first="Paul G" last="Richardson">Paul G. Richardson</name><name sortKey="Usmani, Saad Z" sort="Usmani, Saad Z" uniqKey="Usmani S" first="Saad Z" last="Usmani">Saad Z. Usmani</name></country><country name="Espagne"><noRegion><name sortKey="Paiva, Bruno" sort="Paiva, Bruno" uniqKey="Paiva B" first="Bruno" last="Paiva">Bruno Paiva</name></noRegion><name sortKey="Blade, Joan" sort="Blade, Joan" uniqKey="Blade J" first="Joan" last="Bladé">Joan Bladé</name><name sortKey="Mateos, Maria Victoria" sort="Mateos, Maria Victoria" uniqKey="Mateos M" first="Maria-Victoria" last="Mateos">Maria-Victoria Mateos</name><name sortKey="Miguel, Jesus San" sort="Miguel, Jesus San" uniqKey="Miguel J" first="Jesus San" last="Miguel">Jesus San Miguel</name><name sortKey="Orfao, Alberto" sort="Orfao, Alberto" uniqKey="Orfao A" first="Alberto" last="Orfao">Alberto Orfao</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Moreau, Philippe" sort="Moreau, Philippe" uniqKey="Moreau P" first="Philippe" last="Moreau">Philippe Moreau</name></region><name sortKey="Avet Loiseau, Herve" sort="Avet Loiseau, Herve" uniqKey="Avet Loiseau H" first="Herve" last="Avet-Loiseau">Herve Avet-Loiseau</name><name sortKey="Harousseau, Jean Luc" sort="Harousseau, Jean Luc" uniqKey="Harousseau J" first="Jean-Luc" last="Harousseau">Jean-Luc Harousseau</name></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Dimopoulos, Meletios" sort="Dimopoulos, Meletios" uniqKey="Dimopoulos M" first="Meletios" last="Dimopoulos">Meletios Dimopoulos</name></region><name sortKey="Kastritis, Efstathios" sort="Kastritis, Efstathios" uniqKey="Kastritis E" first="Efstathios" last="Kastritis">Efstathios Kastritis</name><name sortKey="Terpos, Evangelos" sort="Terpos, Evangelos" uniqKey="Terpos E" first="Evangelos" last="Terpos">Evangelos Terpos</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Goldschmidt, Hartmut" sort="Goldschmidt, Hartmut" uniqKey="Goldschmidt H" first="Hartmut" last="Goldschmidt">Hartmut Goldschmidt</name></region><name sortKey="Hillengass, Jens" sort="Hillengass, Jens" uniqKey="Hillengass J" first="Jens" last="Hillengass">Jens Hillengass</name></country><country name="Australie"><noRegion><name sortKey="Spencer, Andrew" sort="Spencer, Andrew" uniqKey="Spencer A" first="Andrew" last="Spencer">Andrew Spencer</name></noRegion></country><country name="République populaire de Chine"><noRegion><name sortKey="Hou, Jian" sort="Hou, Jian" uniqKey="Hou J" first="Jian" last="Hou">Jian Hou</name></noRegion><name sortKey="Chen, Wenming" sort="Chen, Wenming" uniqKey="Chen W" first="Wenming" last="Chen">Wenming Chen</name></country><country name="Singapour"><noRegion><name sortKey="Chng, Wee Joo" sort="Chng, Wee Joo" uniqKey="Chng W" first="Wee Joo" last="Chng">Wee Joo Chng</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Zamagni, Elena" sort="Zamagni, Elena" uniqKey="Zamagni E" first="Elena" last="Zamagni">Elena Zamagni</name></noRegion><name sortKey="Cavo, Michele" sort="Cavo, Michele" uniqKey="Cavo M" first="Michele" last="Cavo">Michele Cavo</name><name sortKey="Palumbo, Antonio" sort="Palumbo, Antonio" uniqKey="Palumbo A" first="Antonio" last="Palumbo">Antonio Palumbo</name></country><country name="Japon"><noRegion><name sortKey="Shimizu, Kazuyuki" sort="Shimizu, Kazuyuki" uniqKey="Shimizu K" first="Kazuyuki" last="Shimizu">Kazuyuki Shimizu</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Johnsen, Hans E" sort="Johnsen, Hans E" uniqKey="Johnsen H" first="Hans E" last="Johnsen">Hans E. Johnsen</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Reiman, Anthony" sort="Reiman, Anthony" uniqKey="Reiman A" first="Anthony" last="Reiman">Anthony Reiman</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Sonneveld, Pieter" sort="Sonneveld, Pieter" uniqKey="Sonneveld P" first="Pieter" last="Sonneveld">Pieter Sonneveld</name></region></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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